eMERGE is a national network organized and funded by the National Human Genome Research Institute (NHGRI) that combines DNA biorepositories with electronic medical record (EMR) systems for large scale, high-throughput genetic research in support of implementing genomic medicine.
Many factors contribute to risk of a disease. Some of these factors are internal, like genetics, and others are external, like where someone lives. Over the last several years researchers have discovered that in addition to one gene being associated with a given disease (monogenic factors), many genes across your genome can contribute to the development of a disease (polygenic factors). To learn more about elements that contribute to risk a disease, click here.
Recent Publications
Shaw DM, Polikowsky HP, Pruett DG, Chen HH, Below JE. Phenome risk classification enables phenotypic imputation and gene discovery in developmental stuttering. American journal of human genetics. 2021 Dec 2;108(12):2271-2283.
Vysotskiy M, Zhong X, Miller-Fleming TW, Zhou D, Weiss LA. Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes. Genome medicine. 2021 Oct 29;13(1):172.
Olson NC, Raffield LM, Moxley AH, Miller-Fleming TW, Reiner AP, et al. Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circulation. Genomic and precision medicine. 2021 Dec;14(6):e003421.