eMERGE is a national network organized and funded by the National Human Genome Research Institute (NHGRI) that combines DNA biorepositories with electronic medical record (EMR) systems for large scale, high-throughput genetic research in support of implementing genomic medicine.
Many factors contribute to risk of a disease. Some of these factors are internal, like genetics, and others are external, like where someone lives. Over the last several years researchers have discovered that in addition to one gene being associated with a given disease (monogenic factors), many genes across your genome can contribute to the development of a disease (polygenic factors). To learn more about elements that contribute to risk a disease, click here.
Recent Publications
Middha P, Thummalapalli R, Quandt Z, Balaratnam K, Ziv E, et al. Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events. medRxiv : the preprint server for health sciences. 2024 Jun 11;.
Cruchaga C, Bradley J, Western D, Wang C, Charles F. and Joanne Knight Alzheimer’s disease research center Knight ADRC, et al. Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways. Research square. 2024 Jun 5;.
Moore A, Ritchie MD. Cross-phenotype associations between Alzheimer's Disease and its comorbidities may provide clues to progression. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science. 2024;2024:623-631.