About

about eMERGE (blue) (web)

eMERGE is a national network organized and funded by the National Human Genome Research Institute (NHGRI) that combines DNA biorepositories with electronic medical record (EMR) systems for large scale, high-throughput genetic research in support of implementing genomic medicine. In its projects, eMERGE studies and pilots genomic medicine translation  through discovery, implementation, tools, and policy. During Phase I – III, the Network deployed 68 electronic phenotype algorithms across more than 100,000 participants with dense genomic data. These algorithms allowed investigators to electronically determine if participants had specific diseases or traits.  Returning genetic clinical results has been implemented multiple times across the Network, including on genes that effect how people metabolize drugs (pharmacogenomics) as well as genes associated with disease traits like Breast cancer or Colorectal cancer. Themes of genomics, bioinformatics, genomic medicine, ethnics, data sharing, privacy, and community engagement are of particular relevance to eMERGE.

eMERGE was initiated in 2007 and included five biorepositories linked to EMRs. eMERGE has expanded throughout the phases to incorporate many more clinical sites, with two focused on pediatrics. A full map of clinical sites and partners can be found here. During the current phase the Network is delving into comprehensive genetic risk, examining genetic risk at multiple sites across the genome (polygenic risk), genetic risk from a single gene (monogenic risk), family history risk, as well as clinical risk. How to combine these risk types and deliver risk assessments to participants and providers is one of the major goals of the Network.

eMERGE is openly interested in collaborations.  Current external collaborations include the ENCODE, IGNITE, the PAGE consortium, and the larger ELSI (Ethical, Legal, and Social Issues) community.  eMERGE is dedicated to developing tools, identifying best practices, and communicating results for participant consent, data sharing, and returning genomic research results, to benefit the broader medical and scientific communities and the general public.

To learn more about us, visit our eMERGE FAQ page.

In the News

Here's what's happening with eMerge:

01
JUL

Read the full press release here. Congratulations to all the sites in the next round of eMERGE! The new clinical sites will be led by: Iftikhar J. Kullo, M.D., at Mayo Clinic, Rochester, Minnesota Dan M. Roden, M.D., at Vanderbilt University Medical Center, Nashville, Tennessee Elizabeth W. Karlson, M.D., at Brigham and Women’s Hospital, Boston Rex […]

08
MAY

The eMERGE Network is excited to share that the MCS NT304, Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in the eMERGE Network; was published on May 7th to American Journal of Human Genetics.

24
MAR

Two companion RFAs for the PRS Diversity Consortium are now published: Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry – Study Sites (U01 Clinical Trial Not Allowed): https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-001.html Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry – Coordinating Center (U01 Clinical Trial Not Allowed): https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-002.html The goal […]

27
FEB

Notice to Encourage Eligible NHGRI Awardees to Apply for PA-18-906 “Research Supplements to Promote Diversity in Health-Related Research” https://grants.nih.gov/grants/guide/notice-files/NOT-HG-19-010.html PIs of active NHGRI research grants can apply; identify eligible individuals, including those from underrepresented groups, for support and mentorship under the auspices of this supplement opportunity. Supplement can support individuals from the undergraduate to the […]