by:

Two companion RFAs for the PRS Diversity Consortium are now published:

• Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry – Study Sites (U01 Clinical Trial Not Allowed): https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-001.html
• Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry – Coordinating Center (U01 Clinical Trial Not Allowed): https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-002.html

The goal of the intended FOAs are to establish Study Sites and a Coordinating Center for PRS Methods and Analysis for Populations of Diverse Ancestry to collaboratively generate and refine PRS for populations of diverse ancestry by integrating existing datasets with genomic and phenotype data for a range of complex diseases and traits. Grantees funded under the intended FOAs will form a PRS Diversity Consortium with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources.

Questions may be directed to:

Lucia A. Hindorff, Ph.D, M.P.H.
National Human Genome Research Institute (NHGRI)
Telephone: 240-271-1509
Email: hindorffl@mail.nih.gov

Damali N. Martin, Ph.D., M.P.H.
National Cancer Institute (NCI)
Telephone: (240) 276-6746
Email: martinda@mail.nih.gov